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CO2 Chromatography (SFC)

Modern CO2 chromatography (SFC) excels in separating, isolating and purifying a wide range of chiral and achiral small molecules, natural products and small peptides relevant to the Pharmaceutical, Agrochemical, Food, Natural Products (Hemp), Chemical Materials, and Environmental industries.

SFC can be seen as another form of liquid and gas chromatography that uses carbon dioxide as the mobile phase.

Benefits of CO2 Chromatography

  1. Cost-Efficient
  2. Fast
  3. Automated
  4. High Productivity
  5. Minimize Waste
  6. One Machine multiple Uses
  7. Sustainable, minimal energy use
  8. CO2 Recycling and Reclaiming

CO2 Chromatography Equipment Range

PIC-Lab Analytical SFC

PICLAB Analytical SFC System
PICLAB Analytical SFC System

PIC-Lab Analytical SFC system is a powerful tool for automated method development and routine analysis/QC/profiling of crude reaction mixtures, purification fractions, natural products extracts and final products. The system is offered with 10 or 20 columns running in parallel for faster analysis.

PIC-Lab Hybrid SFC System

PICLab Hybrid SFE/SFC System
PIC-Lab Hybrid SFE-SFC System

Our PIC-Lab Hybrid SFC is a “One Machine – Multiple Use” system providing both automated analytical method development and semi-preparative purification.

The system is ideal for rapid selection of optimal stationery and mobile phases, scale-up studies and purification.

PICLab Hybrid SFE – SFC System is compact to carry out method development, preparative separation and fraction analysis. For chiral/achiral small molecules, peptides and natural products

PIC-Lab PREP 100 SFC System

PIC-Lab PREP 100 SFC is the only open-bed, preparative scale SFC system with CO2 recycling and a GLS technology enabling clean collection of up to 95% of fraction tube volume. Designed for efficient mass-, UV- and/or time-controlled purification in a non-stacked or stacked injections mode. Automation of analytical method development and analysis of collected fractions can be achieved with the optional analytical SFC module. Production of 3 – 30 g/day of the compound.

PIC-Lab SUPER SFC system

PIC-Lab Super SFC
PIC-Lab Super SFC.

Is a fully automated system for production scale purification of enantiomers and complex mixtures of small molecules, peptides and natural products including cannabis/hemp extracts

The range has flow rates varying between 200-800 mL/min to allow purification of hundreds of 40 grams to 20 kilograms of sample per day. Specific instrument sizes can be designed to fit your workflow and for processing the amount of sample you need to purify. 

These “One Machine – Multiple Use” systems can be upgraded to also perform in-line or independent CO2 Extraction.


Industrial-scale SFC purification at a flow rate of 1000 mL/min or greater is available to accommodate 7.6-30 cm i.d. DAC columns. This system is for facilitating daily automated multi-kilogram purification of small molecules, Hemp extracts and other natural products.