Description

PIC-Lab PREP 100 SFC

PIC-Lab PREP 100 SFC is a new generation, “open bed collection” system.

Such systems allow routine UV and mass-triggered purification of small molecules, peptides and natural products.

This instrument is ideal for drug and phytochemistry research.

It is designed for automated mg to multi-gram separations. The instrument is ideal for purification of chiral and achiral single molecules or libraries.

When the open bed module is removed, the PIC-Lab PREP 100 SFC processes separations by traditional methods.

Key features

• Proprietary GLS technology: Optimal GLS for accurate and clean collection, allowing up to 95% of fraction tube capacity to be filled
• CO2 recycling is supported by a maximum flow rate of 100 ml/min
• Separate injection and collection: For optimal speed and reliability, the injection module is separate from the collection module.
• Both the injection and collection modules have a flexible layout. It accepts 96-well plate footprint or racks depending on your needs.
• Stacked and non-stacked injections: Non-stacked injections are ideal for library purification. Stacked injections can be performed with the injection robot to enable rapid singleton separation. Alternatively, stacked injections are possible with the collection robot when automated separation of half a dozen or more chiral/achiral compounds is required, each requiring multiple injections.
• Device control: All system operations are controlled by a programmable logic controller (PLC), which ensures high reliability and robustness.
• The user can operate the instrument for sequence programming, fraction tracking and data visualization via the user-friendly PIC Solution proprietary software

PIC-Lab PREP 100 range

1. PIC-Lab PREP 100 SFC
2. PIC-Lab PREP 100 MS HT SFC

PIC-Lab PREP 100 SFC

Specification

1. Production capacity 3-25g/day
2. Maximum flow rate 100 ml/min
3. Column size 10, 20 & 30 mm i.d.
4. Column switching 1-4 prep columns
5. Co-solvent Flow rate max. 50 ml/min
6. CO2 supply Gaseous or liquid CO2 at 50 bar
7. Co-solvent switching Up to 4 solvents
8. Maximum pressure 300 bar
9. Temperature range: ambient up to 60°C
10. Open bed Collection 10 well plates (96 well plate footprint), 2 x 121 tubes, 2 x 64 tubes
11. Injection module: 4 well plates (96-well plate footprint), 3 x 36 tubes
12. CO2 recycling: Yes
13. Dimensions ((LxWxH), benchtop): 7’5 “x2’6 “x3’7”

PIC-Lab Prep 100 MS HT SFC

PIC-Lab PREP 100 MS HT SFC-allows automated analytical method development and automated analysis of collection fractions

Innovative, environmentally friendly and sustainable open collection system for routine mass and UV triggered and UV triggered purification of small molecules, peptides and natural products.

Designed for automated mg to multi-gram separations of single molecules or libraries of chiral and achiral compounds.

Key features

• MS, UV, and time detection
• Proprietary GLS for optimal open bed collection and efficient CO2 recovery
• Accurate, efficient and clean collection up to 95% of fraction tube volume
•  Collection separate from injection for short cycle times, high speed, robustness and reliability
• Non-stacked injections ideal for library purification
• Stacked injections ideal for separation of single compounds or automated purification of half a dozen compounds or more, in gram quantities per piece.
• Automated switching valves for selection of preparative columns and 4 co-solvents.

Specifications

1. – Production capacity 5-40g/day
2. – Accurate mobile phase composition by introduction of co-solvent at constant pressure
3. – UEFE-SFC (X-injection) possible
4. – Collection and injection modules with flexible layout (96-well plate footprint or racks)
5. – Programmable logic controller (PLC) for operational control of the unit, PLC guarantees maximum robustness, reproducibility and reliability.
6. – Easy-to-use software with excellent processing and visualisation of data
7. – Up to 4 preparative columns
8. – UV, ELSD, CAD, MS and time collection
9. – 4 fractions and 1 waste with highly efficient GLS for maximum recovery
10. – Efficient CO2 recovery
11. – Accurate mobile phase composition thanks to precise addition of co-solvent at constant pressure.
12. – One-click conversion to stacked injection sequence
13. – Production capacity 5-40g/day
14. – Maximum flow rate 200 ml/min (LEWA diaphragm pump)
15. – Column size 20 & 30 mm i.d
16. – Column switching 1-4 Prep column
17. – Co-solvent flow rate max. 100 ml/min
18. – Co-solvent switching Up to 4 solvents
19. – CO2 supply Gaseous or liquid CO2 at 50 bar
20. – Maximum pressure 350 bar
21. – Temperature 15 to 60°C
22. – Collection 4 (5 as option) fractions plus waste
23. – CO2 recycling Yes (optional)
24. – Size Free-standing frame (L x W x H : 130 x 60 x 120 cm, 51x23x47 in)
25. – Power requirement: V

Please check alternative systems below