Description
PIC-Lab SFx 600 is a fusion technology that integrates SFE and SFC into one device. This system follows the principle “One device – Multiple applications”.
This system is designed to simplify processes and reduce costs.
PIC Solution devices can either be used for separation on a stationary phase or switched to an extraction process.
To enable standard extraction, an appropriately sized extraction vessel is connected to the SFx unit and the extraction steps are activated using our proprietary technology and software.
Key features
- – Two instruments in one – for environmentally friendly and sustainable processing
- – CO2 diaphragm pump is highly accurate, durable, reliable and highly efficient
- – Stacked injection with seamless injection module for fast and reliable cycles.
- – Back-pressure regulator based on a robust and intelligent PIC solution
- – Detection with standard UV detectors (additional detectors can be supplied)
- – The operation of the unit is controlled by a Program Logic Controller (PLC), which ensures continuous operations, reliable cycles and robustness.
- – The user-friendly, proprietary PIC Solution software serves as an interface for preparing programming sequences and visualising data.
PIC-Lab SFx Fusion Range
- PIC-Lab Extraction Injection (X-Injection) Technique
- PIC-Lab SFx 600 (SFE-SFC)
PIC-Lab Extraction-Injection (X-Injection) Technique
The Extraction-Injection technique (X-Injection, SFE-SFC technique) developed by PIC Solution is available for our semi-preparative and preparative systems and helps you to purify poorly soluble samples, accelerate the isolation of minor impurities and separate sensitive compounds.
The extraction-injection technique uses an extractor to dissolve the dry sample or biomass in the supercritical fluid before injection into the stationary phase.
Our SFE-SFC technique is compatible with stacked injections and results in reproducible separations with excellent peak shapes. The amount of sample injected can be adjusted by changing the time, temperature and pressure of the extraction. Since the sample is dissolved in the mobile phase, the possibility of sample precipitation is eliminated.
Process flow
- fill sample into the extractor
- connect the extractor to the instrument
- develop method and test
- produce
Reference:
– Shaimi M. and Cox G.B., A Practical Comparison of Injection Procedures for Preparative SFC, Poster, SFC 2014, 2014 Basel, Switzerland.
– Shaimi M. and Cox G. B., Injection by Extraction: A Novel Sample Introduction Technique for Preparative SFC. Chromatography Today, 2014, 7, 4, 42
– Geoffrey B Cox, Injection by extraction in preparative SFC; isolation of impurities and natural products Chromatography Today, 2016, 9, 3, 16
PIC-Lab SFx 600
This instrument does both, extract, purify and isolate. It is particularly suitable in the drug discovery of compounds and natural products such as cannabinoids
Key features
- – Two instruments in one – for an environmentally friendly and sustainable processing.
- – The CO2 diaphragm pump is highly accurate, durable, reliable and highly efficient.
- – Stacked injection with seamless injection module for fast and reliable cycles
- – Back-pressure regulator based on a robust and intelligent PIC solution
- – Detection with standard UV detectors
- – The operation of the unit is controlled by a Program Logic Controller (PLC), which ensures continuous operations, reliable cycles and robustness.
- – The user-friendly, proprietary PIC Solution software serves as an interface for preparing programming sequences and visualising data.
Specification
- product name: PIC-Lab SFx 600
- production capacity 1-2 kg biomass per 5L extractor
- 5L or 10L extractors (1-2 in series or parallel)
- column size 50, 76 cm i.d.
- fully automatic extraction sequences
- maximum flow rate 400 ml/min (LEWA membrane pump)
- maximum pressure and temperature: 350 bar, 20 to 60°C
- co-solvent pump
- co-solvent exchange : up to 4 solvents
- co-solvent flow rate: max. 250 mL/min
- UV detector
- pressure, flow and co-solvent gradients
- multiple fractions (terpenes, oils, waxes)
- high quality patented operating pressure regulator
- gaseous or liquid CO2 supply
- efficient CO2 recovery
- process logic control (PLC) ensures high robustness, reproducibility and reliability
- collection: 3-4 fractions plus waste
- freestanding frame size: (140 x 75 x 180 cm, 55x29x71 in)
- power requirements 208 V 3-phase / 30 A